Applying one-molecule optical and AFM imaging and power-spectroscopy methods, we seek to unravel the mechanistic components of the framework and dynamics of chromosomes. Our study pursuits include things like:
Our team scientific tests bacterial mobile division and is also aiming to constitute a ‘base up biology’ in artificial cells that will autonomously divide. Our key fascination lies in mobile division, chromatin framework, and spatial Management.
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Nanofabrication of electrodes with sub-five nm spacing for transport experiments on solitary molecules and metallic clusters
We develop issue-of-care diagnostics check of neglected tropical diseases in just source-restricted configurations, based upon Crspr/Cas9 detecting of pathogen’s DNA in overall body fluids.
Our study ranges in the biophysics of DNA to synthetic cells and beyond. Be sure to take a look down below within the spectrum of our latest initiatives.
What distinguishes biology from chemistry is these components jointly make up a living process. The secret of explained lifestyle, I feel, lies in the interactions, the interplay of Those people molecules. The large problem regarding the origin of everyday living is still unanswered. How did we at any time evolve from very simple molecules in to the particularly complicated programs we see today? We don't know. I would like to work on these kinds of massive, open up concerns.’
Nanopores symbolize an elegant and flexible Instrument to measure single molecules. We research novel detection modes with solid-state nanopores as well as various ways to evaluate proteins with nanopores. Jobs encompass the subsequent:
What if, https://www.ceesdekker.net in place of making use of conventional prime-down silicon electronics, transistors might be designed from the bottom up working with single organic and natural molecules as the switching features? This idea, which grew to become The premise of today’s subject of molecular electronics, initial emerged from the 1970s.
There was one problem although — we did not observe any measurable electrical conduction from the single polymer molecules. We concluded that at The only-molecule degree, conducting polymers have been in fact not these good conductors, which was alternatively disappointing. We thus broadened our view to try to find more promising molecules.
‘The idea that There is certainly this type of matter to be a beginning, a large bang, is previously a fascinating signpost to look at that there was a creator. But more usually, and on The idea of pure rationality, I also arrive at a Christian interpretation of actuality. An atheistic worldview can be a naturalistic worldview: basically, there are actually only atoms and natural forces that we can measure.
‘That fears the synthetic mobile, as Element of the Dutch BaSyC initiative. Craig Venter looked top rated-down in These days and discovered about five hundred genes which might be minimally demanded to get a operating mobile. We want to search base-up: how can we move from a number of molecules to an entire biological program?
Visualization of unstained DNA nanostructures with Innovative in-emphasis transmission electron microscopy procedures
Strong-state nanopores have confirmed to become a astonishingly flexible probe for single-molecule analysis of DNA. I will explain several of our new results – exclusively DNA knots – and also our initiatives to grow the capabilities of strong-state nanopores even further more, during the course of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.